By George M. Rodgers
This entire quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and scientific learn. The 9 authoritative chapters commence with a historic standpoint by way of exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising examine topics for ADAMTS13 are coated, together with its power function in angiogenesis and different facets of telephone biology. extra subject matters contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and bought ADAMTS13 deficiency. A bankruptcy on similar thrombotic microangiopathic (TMA) issues examines the variations among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy reports the initial details on rising facets of ADAMTS13, reminiscent of the prestige of recombinant ADAMTS13 items and their strength utility.
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and affliction is an important source for medical hematologists, transfusion medication physicians, and researchers drawn to hemostasis, vascular biology, biochemistry, and metalloproteases.
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ADAMTS13: Biology and Disease by George M. Rodgers